Antibody Anti H1N1pdm09 Detection From Influenza a Outbreak Cases in Indonesia 2009

摘要

Background: Influenza A virus infection can cause pandemic influenza worldwide. The outbreak of the H1N1 virus occurred in Indonesia in April 2009. A total of 1892 suspected cases of H1N1 were reported between April and the end of December 2009. From 1892 suspected cases, there were only 809 confirmed infected by the H1N1 virus. Since the virus is a new strain, we wanted to know how many cases developed antibody anti H1N1 after the first infection occurred. Methods: We used archived sera which was collected in 2009 and stored at -70oC in the virology laboratory of the National Institute of Health Research and Development. We used the HI assay to determine the immunity after infection of Influenza A/H1N1pdm09 in 2009. Results: Only a small proportion of cases infected during an outbreak of flu A/H1N1pdm09 develop protective antibodies anti H1N1pdm09. Of 205 sera were examined, 38 cases (18.5%) developed anti H1N1pdm09 with HI antibody titer ≥1:40. Conclusion: A total of 18.5% of cases develop antibodies anti H1N1pdm09 among A/H1N1pdm09 flu cases during the 2009 outbreak. (Health Science Indones 2013;1:37-40)